trends & perspectives in clinical research

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Patient-led Trials: A Formula for Success

by Craig Morgan

Today patients are taking more responsibility for their own care as they search the nearly infinite amount of data available on the internet. New technologies have enabled patients to become more connected and empowered; with patients generating and sharing data.

Patient-led Trials: A Forumula for Success

Recognizing the opportunity to engage with highly motivated patients and/or patient organizations to both reduce cost and improve success in clinical trials, pharmaceutical companies are beginning to explore the concepts of patient-centric and patient-led clinical trials (PLCTs).

The Terminology: Patient-Led and Patient-Centric Clinical Trials

The majority of clinical trials are still conducted as they always have been, with all trial-related activities being controlled and organized by the sponsor or contract research organization (CRO), with very little, if any, opportunity for patient involvement or input.

Patient involvement can best be described as a continuum. At one end of the spectrum is PLCTs, in which patients take on full ownership of all aspects of the study, including: recruitment, protocol development, data gathering and analysis.

Next is patient-centered research, as patient involvement decreases along the continuum, where the existing research structure, with sponsors in charge and sites conducting the research, remains intact. Patient-centered clinical trials use the traditional randomized clinical trial (RCT) format, but engage with patients in order to more fully understand their needs, and/or to seek advice to help make the trial run more smoothly and efficiently, and ultimately more successfully. In some cases, patients with the condition being studied are even brought into the process of conducting the trial - possibly helping to design the study protocol, determine important research questions or outcome measurements, facilitate effective recruitment, etc.

At the other end of the spectrum, with virtually no patient involvement, other than to serve as subjects for the study, is the 'status quo' or traditional RCT.

Patient-led Clinical Trials in Practice

In a recent survey of 273 senior executives from the life sciences sector, 53% of respondents revealed that becoming more patient-centered in their R&D strategy was a top priority, while nearly two-thirds of respondents indicated that their company had recently increased the level of funds expended on learning about patients. One of the key drivers of industry efforts to increase patient-centeredness in clinical trials is the desire to demonstrate compelling value to both payers and patients alike.

Several patient-led studies have been conducted to investigate the particularly devastating neurological condition, amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease.

In 2008, the first patient-led study was organized as a follow-on to an encouraging Phase I trial that treated subjects with lithium carbonate. Some 350 ALS sufferers participated in the patient-led study that was organized online, with data being collected and analyzed in 3 month intervals with results posted on the project's website. Much to the dismay of the participants, reviews published at the 3 and 6 month intervals on the project website showed no significant evidence that lithium was effective in slowing the progression of ALS, prompting most participants to stop using the drug.

Another prominent patient-led study currently being undertaken in Europe was organized by the AKU Society. Alkaptonuria (AKU) is a rare genetic metabolic disorder causing progressive arthritis of the spine and large joints. This patient-led effort is designed to evaluate optimum dose, efficacy and the optimal age to begin treatment for the drug nitisinone. In what may be an effective model for patient-led studies of the future, this patient-led effort utilized partnerships with groups in industry. The key event which finally got this study off the ground after years of fundraising was a $6 million (Euros) grant from the European Commission.

The idea of patient-led trials is being to gain significant attention within the pharmaceutical industry with conferences dedicated to exploring how to collaborate with patients and patient groups for better trial outcomes.

Challenges Ahead

While PLCTs hold much promise for lowering costs and contributing valuable information to the drug development process, safety is an inherent challenge. Will patients be able to consistently assess that an experimental drug may cause harm, if researchers and regulatory agencies are not consistently able to do so?

Another issue is bias. Members of patient organizations like PatientsLikeMe may not be representative of the general population. Paul Wicks, Vice President of PatientsLikeMe, noted, "when we've compared the PatientsLikeMe sample, for instance in multiple sclerosis, with a tertiary research centre in Boston that sees thousands of patients, we found the group of people who self-report and join PatientsLikeMe tend to be younger, are more likely to be female, and tend to be slightly better educated."

There are also several issues that tend to make pharmaceutical companies weary of patient-led trials. One example is that these types of unregulated activities may adversely affect company-initiated regulated drug development efforts already underway. Given that patient-led trials can have safety issues, the fear is that if harm occurs in a patient-led trial, entire drug development programs could be forced to shut down based on results from one poorly controlled trial. Additionally, there is fear that patient self-experimentation may inhibit people from signing up for RCTs – why sign up for a trial where you might get a placebo if you can obtain the experimental drug on your own?

Lessons Learnt

The next generation in clinical research (and efficiency) must evolve to leverage engaged patients, a vital resource for improving the drug development process. Despite challenges associated with PLCTs, lessons have emerged from this grand experiment. By partnering with patient-advocacy groups for recruitment, follow-up, and even data collection (particularly for patient-reported outcomes), sponsors may help keep patients engaged longer and derive higher quality data sets. With regards to data transparency, the ALS study illustrated that when patients share results with each other, efficacy and safety concerns may come to the forefront more quickly.

Patient-led studies have been a disruptive force in challenging the 'status quo' of the RCT. In the end, it may come down to lessons learnt from this initiative to designing more patient centric studies in the future.

Article published in PharmaPhorum, May 2017

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